221 -

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D
, , ...
    D
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-
  -
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. `
,
:
      ,
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`
- (colorectal)
: ` . (-), , ", , . ...
        - (colorectal)
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: ` -
- - `
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    –
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- Insulin-like growth factor I
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       -   Insulin-like growth factor I
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Insulin-like growth factor I- : ` . - (IGFs), , , () , -...
       -
- : ` . ", , -"smoking gun" , -" ". , , ...
(colo-rectal cancer)
- : ` . ( ), ", . , -40 50% , ...
        (colo-rectal cancer)
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15 . (SPF) ...
`: : .
- : ` . 2004 International Journal of Epidemiology ...
 `:       :     .
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   -
: Tamoxifen
: ` -
: Tamoxifen
 :       Tamoxifen
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