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    `, , , (turnover) .

    :

    ' - , , , -; , , -.

     

    ' -1-2% , 55 , 8% -5% -70 .

    , , (turnover) , () () , , .

    (70% ), (55% ), (53%), (42%), (32%). .

    ', , , , - , , , , .

     

    , "" ', - -25 .

    , " ' -80, . וּ ' , : , ' - , .

    , osteitis deformans, , .

     

    " "-, , , , .

    ' (fibrosis) , (vascularity) , . , - , ( woven bone) , .

     

    ' "" -paramyxo, (measles) -CDV canine distemper virus, , PCR  -100% '.

    40 , -50% .

    , 10% -40% . .

    , , ' - , (bone scan), , . 

     

    : : , , , .

    , , .

    alkaline phosphatase , .

    ' -, - , , .

    ' , ', , .

    '. , ' "-" וּ . ' , .

     

    ' , ,- , , וּ . ', ', -3.1 -, ', -70% , '.

    ', ( -60%), tinnitus ( -50%), dizziness ( -30%), ( -2.1),- ( -70%), ' -20%.

    ' (bowing) . , ' . ' , ().

    , ' . ', , .

     

    ' , -15% , . בּ () , , , .

    ' "'" , , , . -0.5% ' , -. ' , , .

     

    ' " ". (precursors) ', , 1,25 dihydroxyvitamin D, RANKL receptor activator for the nuclear factor κB, , -κB.

    ', , ' .

     

    ' -15% ', , ' -7 -10 ', .

    2006 -Journal of Bone & Mineral Research,   -4 ' '. ' , -Sequestosome 1 SQSTM1, p62, NFκB. SQSTM1 -ubiquitin , , -20 50% ' . ' .   


      ': , . :

    1.etidronate ( -Didronel), 200 400 -3 6 . 400 , -3 . -6 , 3-6 . , .

    2.pamidronate ( -Aredia), - 4 30 60 , 3 .

    3.alendronate ( -Fosamax) 40 6 . 30 . .

    5.clodronate ( Loron  -Bonefos), 400 1,600 6 , 300 5 .

    4.tiludronate ( -Skelid), 400 , 3 , .

    6.risedronate ( -Actonel) 30 , , 30 .

    7. zoledronic acid--( Aclasta), 5 .

     

    - pamidronate , risedronate , etidronate -tiludronate ', (turnover). -risedronate.

    -10 25% -pamidronate , . risedronate   , , tiludronate  -etidronate . 

     

    ', D , , , . -etidronate -80 (osteomalachia), pamidronate , .

    D, D .

    -tiludronate,riosedronate ,alendronate   , '.

    , ' 1,000 1,500 , D, 400 . ' , , .  

     

    ', . Miacalcin, , 50 100 , , 6 18 . , . ', ' () -, .

      . -, , .

     

    ': ', , -, , . , , .

    , . ' , , , -.

    , , , .

     

    : (alkaline phosphatase), ', . .

    , , (), , -ALT  -,AST '. -70, , 10,000 etidronate . , , -risedronate.

     

    , ' -


    10/08/2008

     
       


    , , " , "
    , " " .

    פּ` - Paget.

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