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  • 5lipo-oxygenase ?
       
     
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    5lipo-oxygenase ?

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    5lipo-oxygenase ?
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    (aneurysm) . , , - (aorta), . ִ -, , . 70% , - , - , , . , - . , 1.8 -2.4 ", 7.0 ". 5.5 " בּ , , . , , 2% , , . , , - . 1998 Lancet "ֶֶ" -2 , 5.5 ", .

    , , . , , . וֹ , ( ) , , (larynx). . ֵ .

    , , . , "" " " , . - , , , , , , . ( -adventitia), - , -media. , .

    , 2001 Colin Funk , -leukotrienes , , -5LO
    5lipo-oxygenase. ? וֹוְִֶֹ (cascade) , , וּ . , .

    -30 , (mediators) , -Eicosanoids. Eicosa "" , , 20 , . - Vane 1971 - , . , thromboxane A2 () , -prostacyclin, . , , , 1975-80, . , -, , , Vane -Samuelsson -Bergstrom 1982. . ( PMN), (Mast cells), . . IgE, ,
    5lipo-oxygenase, 5LO, PMN, , . , 5LO FLAP, (co-factor) 5LO, . וּ LTA4, LTB4 -LTC4, , LTD4 -LTE4. C4, D4 -E4 slow reacting substance of anaphylaxis, - .

    5LO ? , LTD4 -LTE4 , - 5LO - FLAP, . -, LTB4, . -LTB4 , , -chemotaxis, . LTB4 MPO myeloperoxidase , -metalloproteinases MMP, -media . , LTB4 , MMP.

    2002 Circulation Research, 5LO . - (knockout mice), -apolipoprotein E -APOE, . -, 5LO -intima -adventitia , 5LO -adventitia. , knockout , 5LO, - -FLAP, - , CysLT1R -CysLT2R , LTD4, ( ) T. , LTD4 (CysLTR) (intima) -media ( -vasa vasorum), MIP-2 macrophage inflammatory protein 2 MIP-1α, MIP -media -adventitia , . , -knockout , APOE 5LO ( 5LO), , -knockout -APOE . 5LO .

    ? . 5LO -cascade , "" . , . 5LO, . , , , , MIP-2, CysLT1R, - FLAP. , . .

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    21/11/2004 18:45:00

     
       


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